Research Proposal: Effects of Maternal Cortisol on Embryonic Neural Development

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dc.contributor.advisorOsovitz, Dr. Michelle
dc.contributor.authorStrzelinski, Hannah
dc.date.accessioned2021-04-29T13:32:40Z
dc.date.available2021-04-29T13:32:40Z
dc.date.issued2021
dc.descriptionRecommended citation: Strzelinski, Hannah. “Research Proposal: Effects of Maternal Cortisol on Embryonic Neural Development.” Q: Journal of Undergraduate Research & Inquiry, 2021. https://doi.org/10.48497/Z2D6-TB68.
dc.description.abstractExpectant mothers who experience periods of increased stress exhibit elevated expression of cortisol, a hormone that binds to glucocorticoid receptors in the hippocampus. Excessive exposure to cortisol can cause damage to glucocorticoid receptors and signal for the downregulation of glucocorticoid receptors – a process which handicaps future recognition of cortisol concentrations as well as the negative feedback loop responsible for regulating cortisol production. Placental transmission of maternal cortisol results in embryonic abnormalities pertaining to brain morphology, psychology, and various cardiovascular and metabolic functions. In this research proposal the expectant model organisms, rats, are given daily injections of 0 (saline), 0.5, or 1.0 mg of hydrocortisone acetate during days 15-19 of embryonic development to mimic periods of increased maternal stress and induce decreased glucocorticoid receptor density in the offspring. Following birthing, the pups are fixed and samples of hippocampal tissue are harvested for the application of a fluorescent antibody that facilitates visualization of glucocorticoid receptors and the subsequent quantification of optical density – a value that is predicted to be inversely proportional to the concentration of hydrocortisone acetate treatments. This essay was written in Dr. Osovitz class.en_US
dc.description.sponsorshipThis volume of Q: Journal of Undergraduate Research & Inquiry was produced in Dr. David Reamer's WRI 376. Q is sponsored by the Office of Undergraduate Research and Inquiry and Dr. Eric Freundt.en_US
dc.identifier.citationStrzelinski, H. (2021). Research Proposal: Effects of Maternal Cortisol on Embryonic Neural Development. "Q: Journal of Undergraduate Research & Inquiry." https://doi.org/10.48497/Z2D6-TB68
dc.identifier.doihttps://doi.org/10.48497/z2d6-tb68
dc.identifier.urihttp://hdl.handle.net/20.500.11868/1674
dc.language.isoen_USen_US
dc.publisherKeyhole Press, The University of Tampaen_US
dc.sourcehttps://utampa.dspacedirect.org/server/api/core/bitstreams/7fb298e9-5548-4198-89b4-9aceb5e72ed1/content?authentication-token=eyJhbGciOiJIUzI1NiJ9.eyJlaWQiOiIwZDMyZGE0Yi1iNGQ2LTQ0MzUtODM5OS1jZDViNTIzYWIwZGUiLCJzZyI6WyI1ODMyNjM1Yy0wNTYwLTQzOTQtYmU5Mi1iNDlkYzllMTg4MDYiLCI1ODMyNjM1Yy0w
dc.subjectGlucocorticoid Cascade Hypothesisen_US
dc.subjectCortisolen_US
dc.subjectHippocampusen_US
dc.subjectStress Responseen_US
dc.subjectNeuroscienceen_US
dc.subjectDevelopmental Biologyen_US
dc.subjectEmbryonic Developmenten_US
dc.titleResearch Proposal: Effects of Maternal Cortisol on Embryonic Neural Developmenten_US
dc.typeArticleen_US

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