Enantioselective Aziridinium/Fluoronium Ion Formation Using Lewis Base Catalysis
Date
2023-04-19
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Honors Program, The University of Tampa
Abstract
Efforts toward establishing the concept of enantioselective Lewis base catalysis with nitrogen sources is reported. This project seeks to
address challenges in alkene amination chemistry by developing diastereo-, enantio- and regioselective addition of nitrogen to alkenes using
Lewis base catalysis to provide advances to the stereoselectivity shortcomings of current approaches. Furthermore, due to the unprecedented
exploration of using non-hypervalent Row 2 electrophiles in Lewis base catalysis, this research offers the potential for groundbreaking
innovation in this field. This report details the investigation of different nitrogen substrates, Lewis base catalysis, and nucleophiles in varied
alkene systems to determine the potential synergy in doing an alkene amination through Lewis base catalysis.
Description
Recommended citation: Garcia, Thalia. “Enantioselective Aziridinium/Fluoronium Ion Formation Using Lewis Base Catalysis.” Honors Program, The University of Tampa, 2023. https://doi.org/10.48497/FD3B-5182.
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Keywords
Nitrogen, Lewis base catalysis, Alkene difunctionalization
Citation
Garcia, Thalia. “Enantioselective Aziridinium/Fluoronium Ion Formation Using Lewis Base Catalysis.” Honors Program, The University of Tampa, 2023. https://doi.org/10.48497/FD3B-5182.